—Christopher P. Cheng, PhD, et al published findings from a study that sought to describe geometric changes of the superficial femoral artery (SFA) resulting from hip and knee flexion in older patients. The investigators noted that vessel deformations have been implicated in endoluminal device fractures, and therefore, better understanding of these deformations could be valuable for device regulation, evaluation, and design. The study was published in the Journal of Vascular and Interventional Radiology (2010;21:195-202).
As detailed by the investigators, the SFAs of seven healthy patients aged 50 to 70 years were imaged with magnetic resonance angiography with the legs straight and with hip and knee flexion. Axial, twisting, and bending deformations were quantified from geometric models constructed from these images.
The investigators found that there was greater shortening in the bottom third of the SFA than in the top two-thirds (top, 5.9% ± 3%; middle, 6.7% ± 2.1%; bottom, 8.1% ± 2% [mean ± SD]; P < .05), significant twist in all sections (top, 1.3 ± 0.8°/cm; middle, 1.8 ± 1.1°/cm; bottom, 2.1 ± 1.3°/cm), and a greater curvature increase in the bottom third than in the top two-thirds (top, 0.15 ± 0.06 cm-1; middle, 0.09 ± 0.07 cm-1; bottom, 0.41 ± 0.22 cm-1; P < .001).
The investigators observed that the SFA tends to deform more in the bottom third than in the other sections, likely because of less musculoskeletal constraint distal to the adductor canal and vicinity of knee flexion. The SFAs of these older subjects curve off axis with normal joint flexion, probably resulting from known loss of arterial elasticity with age. This slackening of the vessel enables a method for noninvasive quantification of in vivo SFA strain, which may be valuable for treatment planning and device design. In addition, the spatially resolved arterial deformations quantified in this study may be useful for commercial and regulatory device evaluation, the investigators concluded.
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